Hydroxyapatite, alginate and gelatin composites used for bone regeneration: a systematic review

Aim: to investigate and describe, through a systematic review, the biological behavior osteogenic potential of composite biomaterials containing hydroxyapatite (HA), alginate gelatin, in different associations, after vivo implantation. Materials Methods: for search selection articles, Medical Literature Analysis Retrieval System Online (PubMed/MEDLINE) Scientific Electronic Library (SciELO) databases were used, published between 2012 2022, using descriptors: “bone regeneration”; “biocompatible material”; “durapatite”; “alginate”; “gelatin”. Initially, an association was made with Boolean operator "OR" descriptors their respective entry terms, considering that MeSH DeCS platforms use terms refer same keywords. Subsequently, "AND" used nine associations descriptors. Results: during searches, 1939 articles located. After inclusion exclusion criteria, 16 studies included review. The main themes found searches were: HA Alginate; Gelatin; HA, Alginate Zinc; Gelatin mesenchymal cells; Chitosan; Silk Fibrin; titanium dioxide; Gelatin. It observed when associated or has improved its properties. Final Considerations: composites gelatin provide range applications promising strategies applied bone repair. Studies have shown these great application Bone Tissue Bioengineering.